Friends tell News 4 that Spade died over the weekend of natural causes.
Spade's son, Michael Boyle, was gunned down at point blank range by a friend of his, Matthew Mahaffey, outside the Freighthouse District in July of 2011.
Mahaffey was an Iraq War veteran and it was never completely clear why he fired at Boyle.
Seven months after the shooting police still had not arrested Mahaffey, even though they knew he had pulled the trigger.
After News 4 got involved and started questioning police and the district attorney's office, Mahaffey was arrested. He eventually pleaded guilty to voluntary manslaughter and is currently serving several months in the Washoe County Jail.
Friends of Joni Spade say she was never able to overcome the loss of her son. She died at the age of 51.